T3577

Tolperisone hydrochloride

≥98% (HPLC), solid

• Synonym(s): Menopatol, 2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one hydrochloride
• Empirical Formula (Hill Notation): C₁₆H₂₃NO · HCl
• CAS Number: 3644-61-9
• Molecular Weight: 281.82
• EC Number: 222-876-5
• MDL number: MFCD00058211
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826771
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white
• solubility: H₂O: >20 mg/mL
• storage temp.: room temp
• SMILES string: Cl.CC(CN1CCCCC1)C(=O)c2ccc(C)cc2
• InChI: 1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
• InChI key: ZBUVYROEHQQAKL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.

Tolperisone regulates ionic currents in myelinates axons and subsequently decreases excitability and mediates its antispastic functions³.

Tolperisone is an ion channel blocker and centrally acting muscle relaxant.

Preparation Note

Tolperisone hydrochloride dissolves in water at a concentration that is greater than 20 mg/ml.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H312 + H332
• Precautionary Statements: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves