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Key Documents

SML3984

Sigma-Aldrich

Insulin sensitizer, C59

new

≥98% (HPLC)

Synonym(s):

N-(4,5-Dichloro-2-pyridinyl)tricyclo[3.3.1.13,7]decane-1-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C16H18Cl2N2O
CAS Number:
Molecular Weight:
325.23
UNSPSC Code:
12352200

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Biochem/physiol Actions

Orally available potentiator of insulin action that significantly improves glucose tolerance in DIO mice; restores insulin-stimulated GLUT4 translocation.



Insulin sensitizer C59 is an orally available potentiator of insulin action that significantly improves glucose tolerance in DIO mice. Insulin sensitizer C59 restores insulin-stimulated GLUT4 translocation without targeting PPARγ. It acts through interaction with Unc119 proteins. C59 lowers fasting blood glucose and plasma insulin concentrations in in DIO mice.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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