SML3435

Momordin Ιc

≥98% (HPLC)

• Synonym(s): (3β)-17-Carboxy-28-norolean-12-en-3-yl 3-O-β-D-xylopyranosyl-β-D-glucopyranosiduronic acid, Mormordin Ic
• Empirical Formula (Hill Notation): C₄₁H₆₄O₁₃
• CAS Number: 96990-18-0
• Molecular Weight: 764.94
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D 12 to 17° in methanol (c=0.5 g/100mL)
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• InChI: 1S/C41H64O13/c1-36(2)14-16-41(35(49)50)17-15-39(6)20(21(41)18-36)8-9-24-38(5)12-11-25(37(3,4)23(38)10-13-40(24,39)7)52-34-29(46)30(28(45)31(54-34)32(47)48)53-33-27(44)26(43)22(42)19-51-33/h8,21-31,33-34,42-46H,9-19H2,1-7H3,(H,47,48)(H,49,50)/t21-,22+,23-,24+,25-,26-,27+,28-,29+,30-,31-,33-,34+,38-,39+,40+,41-/m0/s1
• InChI key: HWYBGIDROCYPOE-WEAQAMGWSA-N

Description

Biochem/physiol Actions

Potent inhibitor of SUMO-specific protease 1 (SENP1) that increases SUMOylated proteins in PC3 cells

Table of Contents

Momordin Ιc, a pentacyclic triterpenoid isolated from fruit of Kochia scoparia (L.) and other medical plants, is a potent inhibitor of SUMO-specific protease 1 (SENP1) that increases SUMOylated proteins in PC3 cells. Momordin Ιc inhibits cell proliferation and induced cell death in prostate cancer PC3 xenograft mouse model. Momordin Ιc decreases serum glucose and ethanol levels after oral administration through acceleration of gastrointestinal transit.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable