SML2726
Endosidin9
≥98% (HPLC)
Synonym(s):
5-Bromo-N-(4-Nitrophenyl)-2-thiophenesulfonamide, ES9
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About This Item
Empirical Formula (Hill Notation):
C10H7BrN2O4S2
CAS Number:
Molecular Weight:
363.21
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Endosidin9 (ES9) is a potent inhibitor of clathrin-mediated endocytosis (CME) in Arabidopsis thaliana, HeLa cells and Drosophila neurons. It binds directly to N-terminal domain of clathrin heavy chain. Also, Endosidin9 is a mitochondrial uncoupler that displays protonophore activities leading to cytoplasm acidification.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Wim Dejonghe et al.
Nature communications, 7, 11710-11710 (2016-06-09)
ATP production requires the establishment of an electrochemical proton gradient across the inner mitochondrial membrane. Mitochondrial uncouplers dissipate this proton gradient and disrupt numerous cellular processes, including vesicular trafficking, mainly through energy depletion. Here we show that Endosidin9 (ES9), a
Wim Dejonghe et al.
Nature chemical biology, 15(6), 641-649 (2019-04-24)
Clathrin-mediated endocytosis (CME) is a highly conserved and essential cellular process in eukaryotic cells, but its dynamic and vital nature makes it challenging to study using classical genetics tools. In contrast, although small molecules can acutely and reversibly perturb CME
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