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Key Documents

SAB4300438

Sigma-Aldrich

Anti-ZAP70 (Ab-493) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLJ17670 antibody produced in rabbit, Anti-FLJ17679 antibody produced in rabbit, Anti-SRK antibody produced in rabbit, Anti-STD antibody produced in rabbit, Anti-zeta-chain (TCR) associated protein kinase 70kDa antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~70 kDa

species reactivity

rat, mouse, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

isotype

IgG

immunogen sequence

(S-Y-Y-T-A)

NCBI accession no.

NP_001070.2

UniProt accession no.

P43403

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ZAP70(7535)

Immunogen

Peptide sequence around aa. 491-495 (S-Y-Y-T-A), according to the protein ZAP70.

Features and Benefits

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Target description

ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Magdalena Witkowska et al.
Cytometry. Part B, Clinical cytometry, 86(6), 410-417 (2014-02-12)
Despite significant progress in treatment, chronic lymphocytic leukemia (CLL) still remains an incurable disease. Major advances have been recently made to understand the molecular pathogenesis underlying CLL, but defects in apoptosis are considered to be the most important factors. Although

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