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SAB4200515

Sigma-Aldrich

Anti-Arc antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-Activity-regulated cytoskeleton-associated protein, Anti-Arc3.1, Anti-Arg3.1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~55 kDa

species reactivity

rat, mouse, human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.0 mg/mL

technique(s)

immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded rat brain
western blot: 1.5-3 μg/mL using U937 cell extracts

UniProt accession no.

Q7LC44

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ARC(23237)
mouse ... Arc(11838)
rat ... Arc(54323)

General description

Activity regulated cytoskeleton associated protein (Arc) is encoded by the gene mapped to human chromosome 8q24.3.

Immunogen

synthetic peptide corresponding to a sequence at the C-terminal region of human Arc, conjugated to KLH. The corresponding sequence is identical in rat and mouse Arc.

Biochem/physiol Actions

Activity regulated cytoskeleton associated protein (Arc) plays a vital role in memory formation. It also facilitates activity-dependent plasticity of dendrites. Mutation in the gene has been associated with the development of idiopathic generalized epilepsy (IGE).

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy.
Haug K
Molecular and Cellular Probes, 14, 255-260 (2000)
Insulin-induced expression of the activity-regulated cytoskeleton-associated gene (ARC) in human neuroblastoma cells requires p21ras, mitogen-activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
Kremerskothen J
Neuroscience Letters, 321, 153-156 (2002)
G L Lyford et al.
Neuron, 14(2), 433-445 (1995-02-01)
Neuronal activity is an essential stimulus for induction of plasticity and normal development of the CNS. We have used differential cloning techniques to identify a novel immediate-early gene (IEG) cDNA that is rapidly induced in neurons by activity in models
Sarah A Stern et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(9), 2179-2190 (2014-03-20)
To treat cognitive disorders in humans, new effective therapies that can be easily delivered systemically are needed. Previous studies showed that a bilateral injection of insulin-like growth factor II (IGF-II) into the dorsal hippocampus of rats or mice enhances fear
Jayme R McReynolds et al.
Neurobiology of learning and memory, 115, 49-57 (2014-09-10)
The basolateral complex of the amygdala (BLA) plays a role in the modulation of emotional memory consolidation through its interactions with other brain regions. In rats, memory enhancing infusions of the β-adrenergic receptor agonist clenbuterol into the BLA immediately after

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