RAB0540
Human FGF19 / Fibroblast Growth Factor 19 ELISA Kit
for serum, plasma, cell culture supernatants and urine
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type urine
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <10%
intra-assay cv: <12%
sensitivity: 30 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FGF19(9965)
General description
This ELISA antibody pair detects human Fibroblast Growth Factor 19.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Fibroblast growth factor (FGF) 19 controls bile acid, fatty acid, glucose and phosphate metabolism in target organs by activating FGF receptor 4. FGF19 regulates hepatic protein and glycogen metabolism via activation of insulin-independent endocrine pathway. In diabetic mice, FGF19 reduces the levels of serum glucose and triglycerides. Overexpression of the gene leads to the development of hepatocellular carcinoma (HCC).
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Description
SDS
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Christian Borup et al.
The American journal of gastroenterology, 115(12), 2086-2094 (2020-08-03)
The diagnosis of bile acid diarrhea is often missed because the availability of the seleno-taurohomocholic acid (SeHCAT) test is limited. We aimed to compare the biomarkers 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor 19 (FGF19) with the SeHCAT test. Patients with
Lixia Gao et al.
Oncogene, 38(13), 2394-2404 (2018-12-07)
The fibroblast growth factor 19 gene FGF19 has previously been reported to be amplified in several cancer types and encodes for a key autocrine signaler known to promote tumorigenic growth. Thus, it is imperative to understand which cancers are oncogenically
Xiangdong Zhao et al.
Molecular carcinogenesis, 57(11), 1616-1625 (2018-08-04)
Although genetic amplification and overexpression of the fibroblast growth factor 19 (FGF19) gene are found in human breast cancer, mechanisms that contribute to such functional alterations remain elusive. We report here that high expression of FGF19 is associated with the
Aze Wilson et al.
Scientific reports, 10(1), 11725-11725 (2020-07-18)
The farnesoid X receptor (FXR) is implicated in Crohn's disease (CD) pathogenesis. It is unclear how genetic variation in FXR impacts CD severity versus genetic variation in nuclear receptors such as pregnane X receptor (PXR) and the multi-drug resistance protein
FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
Kir S, et al.
Science, 331(6024), 1621-1624 (2011)
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