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N7778

Sigma-Aldrich

7-Nitroindazole

≥98%

Synonym(s):

7-NI

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About This Item

Empirical Formula (Hill Notation):
C7H5N3O2
CAS Number:
2942-42-9
Molecular Weight:
163.13
EC Number:
220-934-4
MDL number:
MFCD00022789
UNSPSC Code:
12352200
PubChem Substance ID:
24278047
NACRES:
NA.77

Quality Level

100

Assay

≥98%

form

powder

solubility

DMF: 50 mg/mL, clear, yellow to orange

storage temp.

−20°C

SMILES string

[O-][N+](=O)c1cccc2cn[nH]c12

InChI

1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)

InChI key

PQCAUHUKTBHUSA-UHFFFAOYSA-N

Gene Information

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)
rat ... Nos1(24598)

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Biochem/physiol Actions

Selective inhibitor of nitric oxide synthase from mouse brain.

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301 - H319 - H351 - H360

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 1B

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Garthwaite
Trends in neurosciences, 14(2), 60-67 (1991-02-01)
Nitric oxide (NO) is a recently discovered and highly unorthodox messenger molecule. Current evidence indicates that, in the CNS, NO is produced enzymatically in postsynaptic structures in response to activation of excitatory amino acid receptors. It then diffuses out to
Philippe Bonnin et al.
International journal of molecular sciences, 21(18) (2020-09-12)
The poly(ADP-ribose) polymerase (PARP) inhibitor PJ34 has been reported to improve endothelial dysfunction in the peripheral system. We addressed the role of PJ34 on the vascular tone and vasoreactivity during development in the mouse brain. Blood flows were measured in
Morten Hedetoft et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 45(3), 335-350 (2018-07-22)
Experiments have shown that hyperbaric oxygen (HBO2) therapy reduces cyanide-induced cerebral distress. The exact mechanism behind HBO2's neuroprotective effect is unknown, but has been proposed to be mediated by an increased neuronal nitric oxide (NO) bioavailability, which may compete with
Anita J Turner et al.
American journal of physiology. Renal physiology, 313(4), F864-F873 (2017-07-07)
Via developmental programming, prenatal perturbations, such as exposure to glucocorticoids and maternal malnutrition alter kidney development and contribute to the development of hypertension. To examine the possibility that alterations in tubuloglomerular feedback (TGF) contribute to the development of hypertension in
Dongmei Wang et al.
Experimental neurology, 239, 111-119 (2012-10-16)
We have previously shown that intrathecal administration of the adrenomedullin (AM) receptor antagonist AM(22-52) produces a long-lasting anti-hyperalgesia effect. This study examined the hypothesis that AM recruits other pronociceptive mediators in complete Freund's adjuvant (CFA)-induced inflammation. Injection of CFA in
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