D8190
3′,4′-Dichlorobenzamil hydrochloride
>98% (HPLC)
Synonym(s):
L-594,881
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About This Item
Empirical Formula (Hill Notation):
C13H12N7OCl3 · HCl
CAS Number:
Molecular Weight:
425.10
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
>98% (HPLC)
form
solid
color
yellow
solubility
DMSO: soluble 30 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
NC1=NC(N)=C(Cl)N=C1C(NC(NCC2=CC(Cl)=C(Cl)C=C2)=N)=O.Cl
InChI
1S/C13H12Cl3N7O.ClH/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8;/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24);1H
InChI key
LPHAOBPPRPXQLQ-UHFFFAOYSA-N
Biochem/physiol Actions
Inhibits Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Friedrich Brunner et al.
Cardiovascular research, 60(2), 355-364 (2003-11-14)
The oxidant species peroxynitrite, the reaction product of nitric oxide (NO.) and superoxide, has been implicated in several pathophysiological conditions of the heart. Here, we studied the mechanism of peroxynitrite-induced cardiac depression using specific drugs and simultaneous analyses of myocardial
C Soto et al.
The Journal of experimental zoology, 289(1), 23-32 (2001-02-13)
The aim of this study was to analyze the relationship of the Na+/Ca2+ exchanger, cytosolic calcium, and chloride to the transepithelial transport of sodium in isolated frog skin. Sodium transport was measured as amiloride-inhibitable short circuit current (SCC). We studied
Shaminder Kaur et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129(4), 435-443 (2009-04-02)
The present study was designed to investigate the possible neuroprotective effect of digoxin induced pharmacological preconditioning (PP) and its probable mechanism. Bilateral carotid artery occlusion (BCAO) of 17 min followed by reperfusion for 24 h was employed to produce ischemia
M N Sharikabad et al.
American journal of physiology. Heart and circulatory physiology, 280(1), H344-H353 (2000-12-21)
The effects of Mg(2+) on reactive oxygen species (ROS) and cell Ca(2+) during reoxygenation of hypoxic rat cardiomyocytes were studied. Oxidation of 2',7'-dichlorodihydrofluorescein (DCDHF) to dichlorofluorescein (DCF) and of dihydroethidium (DHE) to ethidium (ETH) within cells were used as markers
Toru Oda et al.
Journal of pharmacological sciences, 116(1), 128-131 (2011-04-28)
To elucidate the role of Na(+)/Ca(2+) exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3',4'-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX
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