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Key Documents

52471

Sigma-Aldrich

Fluorescein isothiocyanate–dextran

average mol wt 2,000,000

Synonym(s):

FITC–Dextran 2000, FITC–Dextran

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About This Item

CAS Number:
60842-46-8
MDL number:
MFCD00131092
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

synthetic

Quality Level

100

conjugate

FITC conjugate

form

powder or crystals

mol wt

average mol wt 2,000,000

extent of labeling

0.001-0.020 mol FITC per mol glucose (substitution)

fluorescence

λex 493 nm; λem 520 nm in 0.1 M Tris pH 8.0

application(s)

cell analysis

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Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran (FITC–Dextran 2000) is use as a fluorescent probe to study the permeability of structures such as intercellular junctions involved in processes such as hearing and vascular permeability and the integrity of the blood brain barrier (BBB).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Elodie Debefve et al.
Lasers in surgery and medicine, 43(7), 696-704 (2011-11-08)
Photodynamic therapy (PDT) affects vascular barrier function and thus increases vessel permeability. This phenomenon may be exploited to facilitate targeted drug delivery and may lead to a new clinical application of photodynamic therapy. Here, we investigate the role of leukocyte
Albert Y Jin et al.
BMC neuroscience, 11, 12-12 (2010-02-04)
The link between early blood- brain barrier (BBB) breakdown and endothelial cell activation in acute stroke remain poorly defined. We hypothesized that P-selectin, a mediator of the early phase of leukocyte recruitment in acute ischemia is also a major contributor
Mercy Afadzi et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 60(1), 21-33 (2013-01-05)
The mechanism involved in the ultrasoundenhanced intracellular delivery of fluorescein-isothiocyanate (FITC)-dextran (molecular weight 4 to 2000 kDa) and liposomes containing doxorubicin (Dox) was studied using HeLa cells and an ultrasound transducer at 300 kHz, varying the acoustic power. The cellular
Guiliang Zheng et al.
BMC neuroscience, 13, 71-71 (2012-06-21)
Exposure to intense noise causes the excessive movement of the organ of Corti, stretching the organ and compromising sensory cell functions. We recently revealed changes in the transcriptional expression of multiple adhesion-related genes during the acute phases of cochlear damage
Sangmi Ock et al.
Biochemical and biophysical research communications, 516(2), 350-356 (2019-06-19)
Receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily. RANKL increases endothelial permeability and induces angiogenesis, suggesting its critical roles in the vasculature. Despite the evidence implicating RANKL in vascular pathology, its role in ischemic retinopathy
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Articles

FITC-labelled polysaccharides

Additional information about FITC-labelled polysaccarides including FITC-Dextran, FITC-DEAE-dextran (FDD), FITC-carboxymethyl-dextran (FCM-Dextran). This page discusses the impact of weight-average molecular weight on the respective molecule dimensions and other physical properties

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