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Key Documents

22630

Sigma-Aldrich

Quinine hydrochloride dihydrate

suitable for fluorescence, BioReagent, ≥98.0% (NT)

Synonym(s):

(8α, 9R)-6′-Methoxycinchonan-9-ol monohydrochloride dihydrate

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About This Item

Empirical Formula (Hill Notation):
C20H24N2O2 · HCl · 2H2O
CAS Number:
Molecular Weight:
396.91
Beilstein:
6112655
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.32

product line

BioReagent

Assay

≥98.0% (NT)

form

powder

optical activity

[α]20/D −230±5°, c = 2% in 0.1 M HCl

impurities

≤10% dihydroquinine hydrochloride (HPLC)

solubility

H2O: soluble

fluorescence

λex 322 nm; λem 450 nm in H2O
λex 347 nm; λem 448 nm in 0.5 M sulfuric acid

suitability

suitable for fluorescence

SMILES string

O.O.Cl.COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1

InChI key

MPQKYZPYCSTMEI-FLZPLBAKSA-N

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Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Carl Esben Poulsen et al.
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The determination of pharmacokinetic properties of drugs, such as the distribution coefficient (D) is a crucial measurement in pharmaceutical research. Surprisingly, the conventional (gold standard) technique used for D measurements, the shake-flask method, is antiquated and unsuitable for the testing
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The intestine is involved in digestion and absorption, as well as the regulation of metabolism upon sensation of the internal intestinal environment. Enteroendocrine cells are thought to mediate these internal intestinal chemosensory functions. Using the CaLexA (calcium-dependent nuclear import of
Colin Harvey-Lewis et al.
Psychopharmacology, 231(13), 2633-2645 (2014-02-19)
Opioid-dependent humans are reported to show accelerated delay discounting of opioid rewards when compared to monetary rewards. It has been suggested that this may reflect a difference in discounting of consumable and non-consumable goods not specific to dependent individuals. Here
Jaekyun Choi et al.
eNeuro, 7(2) (2020-03-30)
Feeding, a critical behavior for survival, consists of a complex series of behavioral steps. In Drosophila larvae, the initial steps of feeding are food choice, during which the quality of a potential food source is judged, and ingestion, during which
Yu-Chieh David Chen et al.
Cell reports, 29(4), 961-973 (2019-10-24)
Taste drives appropriate food preference and intake. In Drosophila, taste neurons are housed in both external and internal organs, but the latter have been relatively underexplored. Here, we report that Poxn mutants with a minimal taste system of pharyngeal neurons

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