E27408

1,2-Dimethoxyethane

ReagentPlus^®, ≥99%, inhibitor-free

• Synonym(s): mono-Glyme, Dimethylglycol, Ethylene glycol dimethyl ether, Monoglyme
• Linear Formula: CH₃OCH₂CH₂OCH₃
• CAS Number: 110-71-4
• Molecular Weight: 90.12
• Beilstein: 1209237
• EC Number: 203-794-9
• MDL number: MFCD00008502
• UNSPSC Code: 12352112
• PubChem Substance ID: 329799037
• NACRES: NA.21

Properties

• vapor density: 3.1 (20 °C, vs air)
• Quality Level: 100
• vapor pressure: 48 mmHg ( 20 °C)
• product line: ReagentPlus^®
• Assay: ≥99%
• form: liquid
• autoignition temp.: 396 °F
• expl. lim.: 10.4 %
• impurities: ≤0.5% (water)
• refractive index: n20/D 1.379 (lit.)
• pH: 7
• bp: 85 °C (lit.)
• mp: −58 °C (lit.)
• density: 0.867 g/mL at 25 °C (lit.)
• SMILES string: COCCOC
• InChI: 1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
• InChI key: XTHFKEDIFFGKHM-UHFFFAOYSA-N

Description

General description

1,2-Dimethoxyethane (DME) is an inert aprotic polar solvent for electrolytes of lithium batteries, polysilicones, oligo- and polysaccharides.

Application

1,2-Dimethoxyethane can be used as a solvent to synthesize:

• Oxazoles from α-acylamino ketones via Robinson-Gabriel reaction.
• 5-Arylhistidines via Suzuki-Miyaura cross-coupling between 5-bromohistidine and arylboronic acids.
• Aryl thioethers via Pd-catalyzed thioetherification of aryl halides with aliphatic and aromatic thiols.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H315 - H332 - H360FD
• Precautionary Statements: P202 - P210 - P233 - P303 + P361 + P353 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Inhalation - Flam. Liq. 2 - Repr. 1B - Skin Irrit. 2
• Supplementary Hazards: EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 41.0 °F - closed cup
• Flash Point(C): 5 °C - closed cup