PHR1700

Ribavirin

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Ribavirin, 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
• Empirical Formula (Hill Notation): C₈H₁₂N₄O₅
• CAS Number: 36791-04-5
• Molecular Weight: 244.20
• MDL number: MFCD00058564
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823563

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to BP 593; traceable to Ph. Eur.; traceable to USP 1602706
• API family: ribavirin
• CofA: current certificate can be downloaded
• packaging: pkg of 1 g
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
• InChI: 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
• InChI key: IWUCXVSUMQZMFG-AFCXAGJDSA-N
• Gene Information: human ... IMPDH1(3614)

Description

General description

Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.

Application

Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H341 - H360FD
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 2 - Repr. 1B
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable