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Key Documents

PHR1580

Supelco

Lauric Acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Dodecanoic acid, Lauric acid, NSC 5026

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About This Item

Linear Formula:
CH3(CH2)10COOH
CAS Number:
Molecular Weight:
200.32
Beilstein:
1099477
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. Y0001474
traceable to USP 1356949

API family

lauric acid

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCCCCCCCCCCC(O)=O

InChI

1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)

InChI key

POULHZVOKOAJMA-UHFFFAOYSA-N

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General description

Lauric acid finds wide applications in cosmetics and food products. It has been tested for its use as an enhancer for topical penetration and transdermal absorption. It is used as a stabilizer for oil-in-emulsions.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Lauric acid may be used as a pharmaceutical reference standard for the determination of the analyte in biopharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Substrate for CYP 4A11

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0576 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Dam. 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

348.8 °F - closed cup

Flash Point(C)

176 °C - closed cup


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Certificates of Analysis (COA)

Lot/Batch Number

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Handbook of Pharmaceutical Excipients, 28(5), 1194-1210 (2009)
Polysorbate 20 degradation in biopharmaceutical formulations: quantification of free fatty acids, characterization of particulates, and insights into the degradation mechanism
Tomlinson A, et al.
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The degradation of polysorbates 20 and 80 and its potential impact on the stability of biotherapeutics
Kishore RSK, et al.
Pharmaceutical Research, 28(5), 1194-1210 (2011)

Protocols

In this study, SPME was used for the analysis of free fatty acids in Parmesan cheese using a 65 μm Carbowax/divinylbenzene (DVB) SPME fiber. Headspace extraction of the cheese sample was conducted at 65 °C for 15 minutes and analyzed by GC with FID detection. SPME is ideal for analyzing the volatiles associated with solid food samples. The phase chemistry of the Nukol GC column provides excellent peak shape of acidic compounds.

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