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Key Documents

A0325200

Alcuronium chloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

N,N′-Diallylnortoxiferinium dichloride

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About This Item

Empirical Formula (Hill Notation):
C44H50Cl2N4O2
CAS Number:
15180-03-7
Molecular Weight:
737.80
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

alcuronium

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

InChI

1S/C44H50N4O2.2ClH/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49;;/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2;2*1H/q+2;;/p-2/b29-13-,30-14-,33-25-,34-26-;;/t31?,32?,39-,40-,41-,42-,43?,44?,47?,48?;;/m0../s1

InChI key

CPYGBGOXCJJJGC-ZHNYPADJSA-L

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Alcuronium chloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Precautionary Statements

P301 + P330 + P331 + P310

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Anaphylactic shock to neuromuscular blocking agent: a familial history.
P Duvaldestin et al.
Anesthesiology, 90(4), 1211-1212 (1999-04-14)
Lauren T May et al.
The Journal of pharmacology and experimental therapeutics, 312(1), 382-390 (2004-08-31)
The effects of prolonged exposure of M(2) muscarinic acetylcholine receptors (mAChRs), stably expressed in Chinese hamster ovary cells, to the allosteric modulators gallamine, alcuronium, and heptane-1,7-bis (dimethyl-3'-phthalimidopropyl)-ammonium bromide (C(7)/3'-phth) were compared with the effects of the agonist carbachol (CCh) and
A Lanzafame et al.
The Journal of pharmacology and experimental therapeutics, 282(1), 278-285 (1997-07-01)
Functional studies were conducted on guinea pig atrial muscarinic acetylcholine M2 receptors with the allosteric modulators heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)ammonium bromide (C7/3'-phth), gallamine and alcuronium to determine whether these ligands are able to recognize a common accessory site. The three modulators inhibited the
C Tränkle et al.
The Journal of pharmacology and experimental therapeutics, 279(2), 926-933 (1996-11-01)
Various compounds are known to allosterically modulate the binding of ligands to muscarinic receptors. Most of these compounds have another predominant pharmacological action. Identification of the potent representatives should be useful for the development of allosteric modulators that are specific
A Krejcí et al.
Molecular pharmacology, 60(4), 761-767 (2001-09-20)
To clarify the involvement of specific domains of muscarinic receptors in the action of allosteric modulators, muscarinic M(3) receptors (on which allosteric interactions are weak) were genetically modified to become more similar to M(2) receptors (on which allosteric interactions are
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