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81148

Sigma-Aldrich

Polyadenylic acid · Polyuridylic acid potassium salt

free from low molecular weight nucleotides, lyophilized

Synonym(s):

Poly(A) · Poly(U) potassium salt

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About This Item

CAS Number:
24936-38-7
MDL number:
MFCD00149034
UNSPSC Code:
41106305

form

powder

quality

lyophilized

mol wt

Mr 5 × 105-16.5 × 106 (5x105-16.5x106; broad molecular weight distribution)
Mr ~8500000

storage temp.

−20°C

InChI

1S/C10H14N5O7P.C9H13N2O9P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1

InChI key

VGQHQOKIMNKUEF-ZLOOHWKQSA-N

Other Notes

base ratio A:U = 1:1
RNA duplex. Useful for studying the area of attachment of nucleic acid mapping reagents: e.g. ethidium; DAPI; methidiumpropyl-EDTA

Quantity

≥20 A260/mg

replaced by

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G Manzini et al.
Nucleic acids research, 13(24), 8955-8967 (1985-12-20)
The interaction of DAPI with natural and synthetic double-stranded polyribonucleotides was studied with different optical and calorimetric methods. The results were similar to those obtained previously with double-stranded polydeoxynucleotides, i.e. two interaction modes, the first of which shows high affinity
J M Kean et al.
Biochemistry, 24(19), 5062-5070 (1985-09-10)
The affinity cleavage reagent methidiumpropyl-EDTA (MPE) [Hertzberg, R. P., & Dervan, P. B. (1982) J. Am. Chem. Soc. 104, 313-315] intercalates between base pairs in helical DNA and, when complexed with Fe(II), cleaves the DNA by oxidative degradation of the
Y Babayan et al.
Nucleic acids research, 15(14), 5803-5812 (1987-07-24)
Base specificity in the interaction of ethidium with double stranded synthetic RNA homopolymers has been studied by means of spectroscopic (UV-visible absorption and fluorescence), microcalorimetric and dilatometric techniques. The results show a strong base specificity in this interaction, the association
Tarita Biver et al.
Nucleic acids research, 38(5), 1697-1710 (2009-12-17)
The interaction of coralyne with poly(A)*poly(U), poly(A)*2poly(U), poly(A) and poly(A)*poly(A) is analysed using spectrophotometric, spectrofluorometric, circular dichroism (CD), viscometric, stopped-flow and temperature-jump techniques. It is shown for the first time that coralyne induces disproportionation of poly(A)*poly(U) to triplex poly(A)*2poly(U) and
H-C Jeung et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 19(3), 520-526 (2007-11-22)
This phase III trial was to compare 5-fluorouracil (5-FU), adriamycin, and polyadenylic-polyuridylic acid (poly A:U) against 5-fluorouracil plus adriamycin (FA) for operable gastric cancer. From 1984 to 1989, patients who had D(2-3) curative resection were randomly assigned to receive chemotherapy
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