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Key Documents

MAB4140

Sigma-Aldrich

Anti-MDR3 Antibody, clone P3 II-26

culture supernatant, clone P3 II-26, Chemicon®

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

300

antibody form

culture supernatant

antibody product type

primary antibodies

clone

P3 II-26, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG2b

suitability

not suitable for immunohistochemistry (Paraffin)

NCBI accession no.

NM_000443.3
NM_018849.2
NM_018850.2

UniProt accession no.

P21439

shipped in

wet ice

Gene Information

human ... ABCB4(5244)

Specificity

This antibody reacts with an internal epitope of MDR3 P-gp. It does not cross-react with the human MDR1 P-gp. It has been reported that this clone also cross reacts with mouse MDR2 Pgp {Kok et al 2003 {http://www.biochemj.org/bj/369/0539/3690539.pdf}.

Immunogen

Mab was selected after immunization with a fusion protein consisting of Gluthatione-S-Transferase and a fragment of MDR3 P-gp comprising aa 629-692.

Application

Anti-MDR3 Antibody, clone P3 II-26 is an antibody against MDR3 for use in WB, IC, IH.
Western Blotting: MDR3 is a 140 kDa protein.

Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations

Immunohistochemistry: 1:20 on acetone-fixed frozen sections

Not suitable for paraffin-embedded tissues

Optimal working dilutions must be determined by end user.

Storage and Stability

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tineke Kok et al.
The Biochemical journal, 369(Pt 3), 539-547 (2002-10-17)
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that controls expression of genes involved in lipid metabolism and is activated by fatty acids and hypolipidaemic fibrates. Fibrates induce the hepatic expression of murine multidrug resistance 2 ( Mdr2 )
G J Hooiveld et al.
Gastroenterology, 117(3), 678-687 (1999-08-28)
Biliary cholesterol secretion is coupled to that of phospholipids in a process controlled by mdr2 P-glycoprotein activity and bile salt secretion. Statins, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been shown to affect hepatobiliary lipid secretion in rats. The aim
Maria Paprocka et al.
European journal of haematology, 99(5), 415-422 (2017-08-15)
It is well established that expression of multi-drug resistance (MDR) proteins (MDR1, BCRP, MDR3, MRP1, and LRP) in leukemic blasts correlates with acute myeloid leukemia (AML) patients' clinical response. Assuming that leukemic stem cells (LSC) are resistant to chemotherapy and
G L Scheffer et al.
Cancer research, 60(18), 5269-5277 (2000-10-04)
Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homologue of MDR1 P-gp

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