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FCMAB110P

Sigma-Aldrich

Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate

clone 10H11.E12, from mouse, PE

Synonym(s):

A-T, mutated

AT mutated

TEL1, telomere maintenance 1, homolog

ataxia telangiectasia mutated

ataxia telangiectasia mutated (includes complementation groups A, C and D)

ataxia telangiectasia mutated protein

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

PE

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

10H11.E12, monoclonal

species reactivity

rat, mouse, human

technique(s)

flow cytometry: suitable

isotype

IgG1κ

NCBI accession no.

NP_000042

UniProt accession no.

Q13315

shipped in

wet ice

target post-translational modification

phosphorylation (pSer1981)

Gene Information

human ... ATM(472)

General description

N-terminal c-Myc, GST-tagged, recombinant human Cardiac Troponin I full length, expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose.

Specificity

Antibody recognizes ATM phosphorylated at Ser1981.
Predicted to cross-react with rat based on sequence homology

Immunogen

Epitope: Phosphorylated at and around Ser1981
KLH-conjugated, synthetic peptide corresponding to human ATM phosphorylated at Ser1981.

Application

Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate detects level of phospho-ATM (Ser1981) & has been published & validated for use in FC.

Quality

Evaluated by Flow Cytometry with HeLa cells.

Target description

~370 kDa Calculated

Physical form

Purified mouse monoclonal IgG1κ conjugated to phycoerythrin in PBS with less than 0.09% sodium azide and 15 mg/mL BSA.

Analysis Note

Control
Irradiated HeLa cells

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Yiting Lim et al.
International journal of radiation oncology, biology, physics, 84(3), 800-806 (2012-03-27)
We have previously shown that the antimalarial agent chloroquine can abrogate the lethal cellular effects of low-dose-rate (LDR) radiation in vitro, most likely by activating the ataxia-telangiectasia mutated (ATM) protein. Here, we demonstrate that chloroquine treatment also protects against lethal doses
Sabrina Fritah et al.
Cancers, 12(9) (2020-09-16)
Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM) recurrence. So far, attempts to characterize factors that contribute to TMZ sensitivity have largely focused on protein-coding genes, and failed to provide effective therapeutic targets. Long noncoding
S Masneri et al.
Stem cell research, 41, 101596-101596 (2019-11-02)
Using a Sendai Virus based vector delivering Yamanaka Factors, we generated induced Pluripotent Stem Cells (iPSCs) from peripheral blood mononuclear cells of a patient affected by Ataxia Telangiectasia (AT), caused by a novel homozygous deletion in ATM, spanning exons 5-7.

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