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AB2204

Sigma-Aldrich

Anti-BMAL1 Antibody

serum, from guinea pig

Synonym(s):

ARNT-like protein 1, brain and muscle, Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, member of PAS protein 3, aryl hydrocarbon receptor nuclear translocator-like, bHLH-PAS protein JAP3, basic-helix-loop-helix-PAS orphan MOP3 2, m

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

guinea pig

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

technique(s)

western blot: suitable

NCBI accession no.

NP_031515

UniProt accession no.

O00327

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ARNTL(406)
mouse ... Arntl(11865)
rat ... Arntl(29657)

General description

Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock.

Specificity

Cat. # AB2204 will recognize the C-terminus of BMAL1.
Reactivity with other species has not been tested.

Immunogen

Epitope: C-Terminus
Recombinant Protein

Application

Anti-BMAL1 Antibody is an antibody against BMAL1 for use in WB.
Research Category
Neuroscience
Research Sub Category
Circadian Rhythm & Sleep

Quality

Routinely tested on C2C12 tissue lysate
Lot Specific Tested Application 1: Western Blot

Target description

~69 kDa

Physical form

Serum with 0.05% NaN3

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Analysis Note

Control
C2C12 Tissue lysate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M K Bunger et al.
Cell, 103(7), 1009-1017 (2001-02-13)
Circadian oscillations in mammalian physiology and behavior are regulated by an endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known as BMAL1) in mice results in immediate and complete loss of circadian rhythmicity in
Rapid resetting of the mammalian circadian clock.
Best, J D, et al.
The Journal of Neuroscience, 19, 828-835 (1999)
Karen J Tonsfeldt et al.
Journal of the Endocrine Society, 3(4), 716-733 (2019-03-25)
In rodents, the preovulatory LH surge is temporally gated, but the timing cue is unknown. Estrogen primes neurons in the anteroventral periventricular nucleus (AVPV) to secrete kisspeptin, which potently activates GnRH neurons to release GnRH, eliciting a surge of LH
Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus.
LeSauter, J; Lambert, CM; Robotham, MR; Model, Z; Silver, R; Weaver, DR
Testing null
Yohei Kobayashi et al.
Neuron, 86(1), 264-275 (2015-03-25)
Circadian rhythms control a variety of physiological processes, but whether they may also time brain development remains largely unknown. Here, we show that circadian clock genes control the onset of critical period plasticity in the neocortex. Within visual cortex of

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