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Key Documents

8.00894

Sigma-Aldrich

N-Ethyldiisopropylamine

for synthesis

Synonym(s):

N-Ethyldiisopropylamine, N,N-Diisopropylethylamine

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About This Item

Linear Formula:
[(CH3)2CH]2NCH2CH3
CAS Number:
7087-68-5
Molecular Weight:
129.24
MDL number:
MFCD00008868
UNSPSC Code:
12352116
EC Index Number:
230-392-0

vapor pressure

14 hPa ( 20 °C)

Quality Level

200

Assay

≥98% (GC)

form

liquid

autoignition temp.

240 °C

potency

200-500 mg/kg LD50, oral (Rat)

expl. lim.

0.7-6.3 % (v/v)

pH

12.3 (20 °C in H2O, as an emulsion)

kinematic viscosity

0.88 cSt(20 °C)

bp

127 °C/1013 hPa

transition temp

flash point 9.5 °C

density

0.76 g/cm3 at 20 °C

storage temp.

2-30°C

InChI

1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

InChI key

JGFZNNIVVJXRND-UHFFFAOYSA-N

General description

N,N-Diisopropylethylamine (DIPEA), also known as Hunig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed in substitution reactions, alkylations, amide couplings, etc. DIPEA is also used as a base in the Pd-catalyzed cross-coupling reactions, which include Heck coupling and Sonagashira coupling reactions.

Application

  • Dual Stimuli-Responsive Hybrid Polymeric Nanoparticles Self-Assembled from POSS-Based: Describes the synthesis of hybrid polymeric nanoparticles using N-Ethyldiisopropylamine in the assembly process (Yang et al., 2022).
  • Magnetical Control of the Charge-Separated State Lifetime Realized by Covalent Attachment of a Platinum Complex: Details the use of N-Ethyldiisopropylamine in the preparation of magnetically controllable platinum complexes (Kozaki et al., 2021).
  • Hybrid block copolymers of polyesters/polycarbonates and polypeptides synthesized via one-pot sequential ring-opening polymerization: Explains the initiation of polymerization with N-Ethyldiisopropylamine for creating hybrid block copolymers (Gradišar et al., 2018).

Analysis Note

Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.755 - 0.758
Water (K. F.): ≤ 0.20 %
Identity (IR): passes test

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.1 °F

Flash Point(C)

9.5 °C

Certificates of Analysis (COA)

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Protocols

Fmoc Resin Cleavage and Deprotection

Fmoc resin cleavage and deprotection follows the difficult task of detaching the peptide from the resin support and removing all the side-chain protecting groups of the amino acid residues to yield the desired peptide.

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