540500

Purvalanol A

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

• Synonym(s): Purvalanol A, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
• Empirical Formula (Hill Notation): C₁₉H₂₅ClN₆O
• CAS Number: 212844-53-6
• Molecular Weight: 388.89
• MDL number: MFCD02179211
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
• InChI key: PMXCMJLOPOFPBT-HNNXBMFYSA-N

Description

General description

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2-cyclin B; IC₅₀ = 70 nM for Cdk2-cyclin A; IC₅₀ = 35 nM for Cdk2-cyclin E; and IC₅₀ = 75 nM for Cdk5-p35).

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2/cyclin B; IC₅₀ = 70 nM for Cdk2/cyclin A; IC₅₀ = 35 nM for Cdk2/cyclin E; and IC₅₀ = 75 nM for Cdk5/p35).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Cdc2/cyclin B

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Gray, N.S., et al. 1998. Science 281, 533.

Legal Information

Sold under license of U.S. Patents 6,617,331 and 6,803,371.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3