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922862

Sigma-Aldrich

TissueFab® bioink 

(GelAlgHA)ma -Vis/405 nm

Synonym(s):

AlgMA, Alginate, Bioink, GelMA, Gelatin, HAMA, Hyaluronic acid

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.23

Quality Level

100

description

Validation : HNMR at 40C

sterility

sterile-filtered (0.2μm)

form

viscous liquid (gel)

IVD

for in vitro diagnostic use

impurities

<5 CFU/g Bioburden

color

pale yellow to colorless

pH

(6.5-7.5)

viscosity

2-25 cP(37 °C)

application(s)

3D bioprinting

storage temp.

2-8°C

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General description

3D bioprinting is the printing of biocompatible materials, cells, growth factors, and the other supporting materials necessary to yield functional complex living tissues. 3D bioprinting has been used to generate several different types of tissue such as skin, bone, vascular grafts, and cartilage structures. Based upon the desired properties, different materials and formulations can be used to generate both hard and soft tissues. While several 3D printing methods exist, due to the sensitivity of the materials used, extrusion-based methods with bioinks are most commonly employed.

Application

HAMA-AlgMA-Gel bioink formulation is derived from natural polymers – Hyaluronic acid, alginate, and gelatin. The natural polymer widely used in tissue engineering, hyaluronic acid, also known as sodium hyaluronate or hyaluronan, is an anionic, nonsulfated glycosaminoglycan (GAG). Alginate also known as sodium alginate or alginic acid, is a polysaccharide widely used in tissue engineering obtained from brown algae. Gelatin contains bioactive peptide sequences similar to a native extracellular matrix which promotes integrin-mediated cell adhesion and MMP sensitive enzymatic degradation which are essential for cellular functions such as migration, proliferation, and differentiation. TissueFab® - HAMA AlgMA Gel-UV bioink formulation is optimized for 3D bioprinting of tissues and constructs using an extrusion-based 3D bioprinter. TissueFab® - HAMA AlgMA Gel-UV bioink formulation can be used to bioprint cell-laden hydrogels in the desired shape without any supporting material and can be crosslinked in one step using exposure to UV light for further culture and maturation of cells for tissue engineering and regenerative medicine applications.

Legal Information

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

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Articles

3D Bioprinting: Bioink Selection Guide

Bioinks can be 3D bioprinted into functional tissue constructs for drug screening, disease modeling, and in vitro transplantation. Choose the Bioinks and method for specific tissues engineering applications.

Recent Advances in 3D-Bioprinting-based Drug Screening

Learn how 3D bioprinting is revolutionizing drug discovery with highly-controllable cell co-culture, printable biomaterials, and its potential to simulate tissues and organs. This review paper also compares 3D bioprinting to other advanced biomimetic techniques such as organoids and organ chips.

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