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920975

Sigma-Aldrich

TissueFab® bioink 

(GelAlgHA)ma -UV/365 nm

Synonym(s):

AlgMA, Alginate, Bioink, GelMA, Gelatin, HAMA, Hyaluronic acid

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.25

Quality Level

100

description

suitable for 3D bioprinting applications

sterility

sterile-filtered

form

viscous liquid (or gel)

impurities

<5 CFU/g Bioburden (Fungal)
<5 CFU/g Bioburden (Total Aerobic)

color

colorless to pale yellow

particle size

0.2 μm

pH

(6.5-7.5)

application(s)

3D bioprinting

storage temp.

2-8°C

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Application

TissueFab®- HAMA-AlgMA-UV bioink is an alginate methacrylate based bioink for 3D bioprinting applications. The formulation is optimized for 3D bioprinting of tissues and constructs using extrusion based 3D bioprinters, and can be can be used to bioprint cell-laden hydrogels in desired shape without any supporting material. The crosslinking of printed structures can be done in one step using UV light for further culture and maturation of cells for tissue engineering and regenerative medicine applications.

This bioink is derived from natural polymers − hyaluronic acid, alginate and gelatin. Hyaluronic acid is also known as sodium hyaluronate or hyaluronan, is an anionic, nonsulfated glycosaminoglycan (GAG). Alginate also known as sodium alginate or alginic acid, is a natural biopolymer obtained from brown algae. Alginate is a natural polysaccharide widely used in tissue engineering. Gelatin contains bioactive peptide sequences similar to native extracellular matrix which promotes integrin mediated cell adhesion and MMP sensitive enzymatic degradation which are essential for cellular functions such as migration, proliferation and differentiation.

Features and Benefits

  • Ready-to-use formulation optimized for high printing fidelity and cell viability, eliminating the lengthy bioink formulation development process
  • Step-by-step protocols developed and tested by MilliporeSigma 3D Bioprinting Scientists, no prior 3D bioprinting experience needed
  • Suitable for different extrusion-based 3D bioprinter model

Packaging

10 mL in glass bottle

Legal Information

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

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Articles

3D Bioprinting: Bioink Selection Guide

Bioinks can be 3D bioprinted into functional tissue constructs for drug screening, disease modeling, and in vitro transplantation. Choose the Bioinks and method for specific tissues engineering applications.

Recent Advances in 3D-Bioprinting-based Drug Screening

Learn how 3D bioprinting is revolutionizing drug discovery with highly-controllable cell co-culture, printable biomaterials, and its potential to simulate tissues and organs. This review paper also compares 3D bioprinting to other advanced biomimetic techniques such as organoids and organ chips.

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