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901397

Sigma-Aldrich

Poly(ethylene glycol) linear dendrimer

NHBoc terminated, PEG Mn 6000, generation 4

Synonym(s):

Dendron bifunctionalized PEG, PFD-G4-PEG6k-NHBoc, Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C678H1202N32O323
Molecular Weight:
14970.82
UNSPSC Code:
51171641
NACRES:
NA.23

Quality Level

100

form

solid

mol wt

PEG Mn 6000

color

white to off-white

storage temp.

−20°C

General description

  • Polymer architecture: Dendron-functionalized PEG
  • Generation: 4
  • PEG Average Mn: 6,000
  • End group functionality: Boc-protected amine
  • No. surface groups: 32
  • Calculated mol. wt.: 14970.98 g/mol
  • Boc: tert-Butyloxycarbonyl
  • Bis-MPA: 2,2-bis(hydroxymethyl)propionic acid

Application

Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. PEG-core dendrimers feature excellent solubility in water and a high degree of functionality per PEG chain, making them strong candidates for advanced drug delivery systems or as targeting vessels. Additionally, the terminal amine groups can readily be used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds, to yield highly functionalized materials for a variety of biomedical applications.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Lot/Batch Number
MKCG5738

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Yanjun Fu et al.
Bioconjugate chemistry, 17(4), 1043-1056 (2006-07-20)
The purpose of this study was to design, synthesize, and initially characterize a representative set of novel constructs for large-molecular radiographic/computed tomography (CT) contrast agents, intended for a primarily intravascular distribution. A new assembly of well-known and biocompatible components consists
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

New Hybridized Multi-Dendrimer Platforms Based on the Supramolecular Assembly Guided by Systematic CNDP Engineering

Dendrimers are macromolecular polymer nanostructures containing symmetrical three-dimensional branching units resembling the branches of trees. These structures have been synthesized for specific objectives by the manipulation of six features referred to as “critical nanoscale design parameters” (CNDPs).

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