900913
Tetrazine-PEG5-NHS ester
≥95%
Synonym(s):
Tz-PEG5-NHS
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About This Item
Empirical Formula (Hill Notation):
C27H36N6O10
CAS Number:
Molecular Weight:
604.61
MDL number:
UNSPSC Code:
12352108
NACRES:
NA.22
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Quality Level
Assay
≥95%
form
powder or crystals
reaction suitability
reaction type: click chemistry
reagent type: linker
functional group
NHS ester
storage temp.
−20°C
SMILES string
O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O
InChI
1S/C27H36N6O10/c34-23(28-19-21-1-3-22(4-2-21)27-31-29-20-30-32-27)7-9-38-11-13-40-15-17-42-18-16-41-14-12-39-10-8-26(37)43-33-24(35)5-6-25(33)36/h1-4,20H,5-19H2,(H,28,34)
InChI key
DUPHIQYIPUTDJS-UHFFFAOYSA-N
General description
Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.
Application
Tetrazine-PEG5-NHS ester (Tz-PEG5-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction.
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 900913-50MG | 4061833251409 |
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