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765589

Sigma-Aldrich

Gold nanoparticles

50 nm diameter, carboxylic acid functionalized, PEG 5000 coated, dispersion in H2O

Synonym(s):

Gold nanoparticles COOH functionalized, Au NP COOH, Gold Colloid

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

material

PEG 5000

Quality Level

100

form

dispersion in H2O
nanoparticles

packaging

poly bottle of 1 mL

OD

50

diameter

50 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

535 nm

functional group

carboxyl

storage temp.

2-8°C

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General description

Carboxylic acid functionalized GNPs forms conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.

Application

Gold nanoparticles 50 nm diameter, carboxylic acid functionalized, PEG 5000 coated, dispersion in H2O can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.
The carboxylic acid group binds with proteins and is used in targeted drug delivery and gene therapy.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Functionalized gold nanoparticles and their biomedical applications
Nanomaterials, 1(1), 31-63 (2011)
Optical Fiber Sensors for Rapid Screening of COVID-19
Nag P, et al.
Transactions of the Indian National Academy of Engineering, 6, 1-4 (2020)
Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain

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