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540323

Sigma-Aldrich

1,1,1-Trifluoro-2-propanol

97%

Synonym(s):

1,1,1-Trifluoroisopropanol, 1,1,1-Trifluoropropane-2-ol, 1-(Trifluoromethyl)ethanol, 1-Methyl-2,2,2-trifluoroethanol

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About This Item

Linear Formula:
CF3CH(OH)CH3
CAS Number:
374-01-6
Molecular Weight:
114.07
EC Number:
206-773-2
MDL number:
MFCD00014403
UNSPSC Code:
12352100
PubChem Substance ID:
24878458
NACRES:
NA.22

Assay

97%

refractive index

n20/D 1.316 (lit.)

bp

81-82 °C (lit.)

density

1.259 g/mL at 25 °C (lit.)

SMILES string

CC(O)C(F)(F)F

InChI

1S/C3H5F3O/c1-2(7)3(4,5)6/h2,7H,1H3

InChI key

GILIYJDBJZWGBG-UHFFFAOYSA-N

General description

1,1,1-Trifluoro-2-propanol, a fluoroalcohol, is an organic solvent. Vibrational spectral analysis of OH and OD groups of 1,1,1-trifluoro-2-propanol and its deuterated derivatives has been conducted.

Application

1,1,1-Trifluoro-2-propanol may be used in the synthesis of 1,1,1-trifluoropropan-2-yl 2-(4-hydroxy-3-methoxyphenyl)acetate and 1,1,1-trifluoropropan-2-yl 2-(3-ethoxy-4-hydroxyphenyl)acetate.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

64.9 °F - closed cup

Flash Point(C)

18.3 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fluoroalcohols-XXI. Infrared, matrix infrared and Raman spectra of 1, 1, 1-trifluoro-2-propanol and its three deuterated analogues.
Murto J, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 31(4), 479-493 (1975)
Synthetic mammalian prions.
Legname G, et al.
Science, 305, 673-676 (2004)
Heng Zhang et al.
PloS one, 9(5), e96518-e96518 (2014-05-07)
Soft drugs are molecules that are purposefully designed to be rapidly metabolized (metabolically labile). In anesthesia, the soft drug is useful because it enables precise titration to effect and rapid recovery, which might allow swift and clear-headed recovery of consciousness

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