[Methods for the protection against counterfeit medications. Part 2. The assessment of interlot dispersion of the metoprolol succinate tablets fabricated by different manufacturers].

[Methods for the protection against counterfeit medications. Part 2. The assessment of interlot dispersion of the metoprolol succinate tablets fabricated by different manufacturers].

Sudebno-meditsinskaia ekspertiza (2013-01-01)

V A Iakushev, M A Morozova, T E Elizarova, S B Fitilev, T V Pletneva

ZUSAMMENFASSUNG

This paper reports the results of analysis of the metoprolol succinate tablets fabricated by two different manufacturers, Akrikhin (Russia) and AstraZeneka (Sweden) by near-IR spectroscopy in the combination with the chemometric processing of the data obtained (discriminative analysis). It is concluded that this method is applicable for the assessment of interlot dispersion of the metoprolol succinate tablets.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

M5391

Sigma-Aldrich

(±)-Metoprolol, ≥98% (titration), powder

M-123

Supelco

Metoprolol tartrate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

PHR1076

Supelco

Metoprolol-Tartrat, Pharmaceutical Secondary Standard; Certified Reference Material

M1830000

Metoprolol -tartrat, European Pharmacopoeia (EP) Reference Standard