- Recoverable fluorous CBS methodology for asymmetric reduction of ketones.
Recoverable fluorous CBS methodology for asymmetric reduction of ketones.
Organic letters (2005-07-16)
Zoltán Dalicsek, Ferenc Pollreisz, Agnes Gömöry, Tibor Soós
PMID16018631
ZUSAMMENFASSUNG
[reaction: see text]. An operationally simple and recoverable fluorous CBS methodology was developed. The in situ-generated fluorous oxazaborolidine efficiently catalyzed the reduction of ketones with high enantioselectivity and reactivity. The subsequent recycling of the fluorous prolinol precatalyst was achieved by fluorous solid-phase extraction.