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Merck

V900425

Sigma-Aldrich

3,4-Dihydroxy-L-Phenylalanin

Vetec, reagent grade, 98%

Synonym(e):

3-(3,4-Dihydroxyphenyl)-L-alanin, L-3-Hydroxytyrosin, L-DOPA, Levodopa

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About This Item

Lineare Formel:
(HO)2C6H3CH2CH(NH2)CO2H
CAS-Nummer:
Molekulargewicht:
197.19
Beilstein:
2215169
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352209
PubChem Substanz-ID:

Qualität

reagent grade

Produktlinie

Vetec

Assay

98%

mp (Schmelzpunkt)

276-278 °C (lit.)

SMILES String

N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O

InChI

1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

InChIKey

WTDRDQBEARUVNC-LURJTMIESA-N

Angaben zum Gen

human ... DRD3(1814)

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Rechtliche Hinweise

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Roshan Cools
Neuroscience and biobehavioral reviews, 30(1), 1-23 (2005-06-07)
It is well recognised that patients with Parkinson's disease exhibit cognitive deficits, even in the earliest disease stages. Whereas, L-DOPA therapy in early Parkinson's disease is accepted to improve the motor symptoms, the effects on cognitive performance are more complex:
A P de Jong et al.
Clinica chimica acta; international journal of clinical chemistry, 171(1), 49-61 (1988-01-15)
L-3-(3,4-Dihydroxyphenyl)alanine (DOPA) and its 3-O-methyl metabolite (OMD) were measured in plasma and cerebrospinal fluid by a new assay which combines N,O-acetylation of amino acids in aqueous media, preparation of pentafluorobenzyl esters under anhydrous conditions, and analysis by gas chromatography-electron capture
Damian M Herz et al.
Annals of neurology, 75(6), 829-836 (2014-06-04)
In Parkinson disease (PD), long-term treatment with the dopamine precursor levodopa gradually induces involuntary "dyskinesia" movements. The neural mechanisms underlying the emergence of levodopa-induced dyskinesias in vivo are still poorly understood. Here, we applied functional magnetic resonance imaging (fMRI) to

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