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1138008

USP

Clindamycinphosphat

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

Clindamycin-2-Phosphat, Clindamycin-2-dihydrogenphosphat

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About This Item

Empirische Formel (Hill-System):
C18H34ClN2O8PS
CAS-Nummer:
24729-96-2
Molekulargewicht:
504.96
MDL-Nummer:
MFCD07793328
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329749424
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

clindamycin

Hersteller/Markenname

USP

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

−20°C

SMILES String

CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O

InChI

1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1

InChIKey

UFUVLHLTWXBHGZ-MWBQRTRKSA-N

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Allgemeine Beschreibung

Clindamycin is a lincosamide antibiotic which is considered as a semisynthetic derivative of lincomycin. It is mainly used as an antimicrobial agent.

Anwendung

Clindamycin phosphate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Clindamycin Phosphate Gel
  • Clindamycin Phosphate Vaginal Cream
  • Clindamycin Phosphate Topical Suspension
  • Clindamycin Phosphate Vaginal Inserts
  • Clindamycin Phosphate Topical Solution
  • Clindamycin Injection

Biochem./physiol. Wirkung

Wirkungsspektrum: Gram-positive Kokken und Taxoplasma. Besonders aktiv gegen anaerobe Bakterien.
Wirkmechanismus: Hemmt die Proteinsynthese in Bakterien durch Bindung der 50S ribosomalen Untereinheit

Sonstige Hinweise

Antibakterielles und antiprotozoales Antibiotikum der Lincosamid-Klasse.
Sales restrictions may apply.

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Ähnliches Produkt

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Preisangaben

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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D W Scott et al.
The Canadian veterinary journal = La revue veterinaire canadienne, 39(12), 753-756 (1998-12-23)
Clindamycin hydrochloride capsules (11 mg/kg body weight, q24 h) were administered orally to 20 dogs with deep staphylococcal pyoderma. Response to therapy was excellent in 100% of the dogs. Duration of therapy varied from 21 to 91 d, with an
Fulminant pseudomembranous colitis caused by clindamycin phosphate vaginal cream.
M F Trexler et al.
The American journal of gastroenterology, 92(11), 2112-2113 (1997-11-15)
James Q Del Rosso et al.
Cutis, 81(5), 405-408 (2008-06-12)
An aqueous gel formulation containing solubilized clindamycin phosphate 1.2% and a stable combination of both solubilized and crystalline tretinoin 0.025% (clin/tret) has been evaluated in 3 pivotal phase 3 studies, among other studies including a 52-week trial. The pivotal studies
Vuk Uskoković et al.
Journal of pharmaceutical sciences, 103(2), 567-579 (2014-01-03)
Nanoparticulate composites of hydroxyapatite (HAp) and chitosan were synthesized by ultrasound-assisted sequential precipitation and characterized for their microstructure at the atomic scale, surface charge, drug release properties, and combined antibacterial and osteogenic response. Crystallinity of HAp nanoparticles was reduced because
Le Ngoc Tran et al.
Journal of chromatography. A, 1356, 289-293 (2014-07-20)
An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clindamycin phosphate (CLIP) as a chiral selector. A sol solution consisting of 6 × 10(-3)M of polyethylene glycol

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