Z0153

ZM 241385

≥98% (HPLC)

• Synonym(e): 4-(-2-[7-amino-2-{2-furyl}{1,2,4}triazolo{2,3-a} {1,3,5}triazin-5-yl-amino]ethyl)phenol
• Empirische Formel (Hill-System): C₁₆H₁₅N₇O₂
• CAS-Nummer: 139180-30-6
• Molekulargewicht: 337.34
• MDL-Nummer: MFCD00908394
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329831597
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: >15 mg/mL
• Lagertemp.: room temp
• SMILES String: Nc1nc(NCCc2ccc(O)cc2)nc3nc(nn13)-c4ccco4
• InChI: 1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
• InChIKey: PWTBZOIUWZOPFT-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

ZM 241385 is a potent selective adenosine A2A antagonist. The A2A receptor plays a role in regulating myocardial oxygen consumption and coronary blood flow and is highly expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. ZM 241385 has neuroprotective effects and is being investigated for use in Parkinson′s and other neurodegenerative disorders.

Leistungsmerkmale und Vorteile

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable