WH0050674M1

Monoclonal Anti-NEUROG3 antibody produced in mouse

clone 4B7, purified immunoglobulin, buffered aqueous solution

• Synonym(e): Anti-Atoh5, Anti-Math4B, Anti-neurogenin 3, Anti-ngn3
• MDL-Nummer: MFCD01633905
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 4B7, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Methode(n): immunofluorescence: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: 1-5 μg/mL
• Isotyp: IgG2bκ
• GenBank-Hinterlegungsnummer: NM_020999
• UniProt-Hinterlegungsnummer: Q9Y4Z2
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... NEUROG3(50674)

Beschreibung

Allgemeine Beschreibung

Neurogenin 3 (NEUROG3) is also termed as Ngn3. This protein belongs to the subfamily of basic-helix-loop-helix (bHLH) transcription factors. It is located on human chromosome 10q.

Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm (Gradwohl et al., 2000 [PubMed 10677506]).[supplied by OMIM]

Immunogen

NEUROG3 (NP_066279, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLN*

Biochem./physiol. Wirkung

Neurogenin 3 (NEUROG3) is required for all intestinal enteroendocrine cells. It participates in the differentiation of endocrine pancreas. This protein is also essential to induce islet cell maturation and to maintain islet function.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Rechtliche Hinweise

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Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)