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WH0001111M5

Monoclonal Anti-CHEK1 antibody produced in mouse

Name: Monoclonal Anti-CHEK1 antibody produced in mouse
Brand: SIGMA

clone 2G3, purified immunoglobulin, buffered aqueous solution

Synonym(e):

Anti-CHK1, Anti-CHK1 checkpoint homolog (S. pombe)

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About This Item

MDL-Nummer:

MFCD02262709

UNSPSC-Code:

12352203

NACRES:

NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

2G3, monoclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Methode(n)

immunofluorescence: suitable
indirect ELISA: suitable

Isotyp

IgG2bκ

GenBank-Hinterlegungsnummer

BC004202

UniProt-Hinterlegungsnummer

O14757

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CHEK1(1111)

Immunogen

CHEK1 (AAH04202, 361 a.a. ~ 476 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKVWLPAT

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Rechtliche Hinweise

GenBank is a registered trademark of United States Department of Health and Human Services

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Analysenzertifikate (COA)

Lot/Batch Number

07096-2G3

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Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks.

Takanori Katsube et al.

Journal of biochemistry, 156(2), 85-95 (2014-04-01)

The nuclear foci of phosphorylated histone H2AX (γH2AX) are frequently used as a marker for DNA double-strand breaks (DSBs) following ionizing radiation (IR). However, recent studies reported that γH2AX foci do not necessarily correlate with DSBs under other conditions. We

Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma.

Yin Xie et al.

Medical oncology (Northwood, London, England), 31(3), 844-844 (2014-01-28)

Checkpoint kinase 1 (CHEK1) is an evolutionarily conserved Ser/Thr kinase, which mediates cell-cycle arrest after DNA damage, and we previously reported that CHEK1 was overexpressed and associated with poor prognosis in hepatocellular carcinoma (HCC), indicating it was oncogenic gene. In

Prostate cancer stem-like cells proliferate slowly and resist etoposide-induced cytotoxicity via enhancing DNA damage response.

Judy Yan et al.

Experimental cell research, 328(1), 132-142 (2014-08-26)

Despite the development of chemoresistance as a major concern in prostate cancer therapy, the underlying mechanisms remain elusive. In this report, we demonstrate that DU145-derived prostate cancer stem cells (PCSCs) progress slowly with more cells accumulating in the G1 phase

Decreased DNA repair activity in bone marrow due to low expression of DNA damage repair proteins.

Eui Young So et al.

Cancer biology & therapy, 15(7), 906-910 (2014-04-24)

The bone marrow (BM) is one of the organs that is sensitive to acute exposure of ionizing radiation (IR); however, the mechanism of its high sensitivity to IR remains to be elucidated. BM is differentiated into dendritic cells (DC) with

Checkpoint kinase inhibitor AZD7762 overcomes cisplatin resistance in clear cell carcinoma of the ovary.

Hiroaki Itamochi et al.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 24(1), 61-69 (2013-12-24)

Checkpoint kinase (Chk) inhibitors are thought to increase the cytotoxic effects of DNA-damaging agents and are undergoing clinical trials. The present study was aimed to assess the potential to use the Chk1 and Chk2 inhibitor, AZD7762, with other anticancer agents

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Global Trade Item Number

SKU	GTIN
WH0001111M5-100UG	4061829596422

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