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V3638

Sigma-Aldrich

Vascular Endothelial Growth Factor 164 from rat

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(e):

VEGF 164, VEGF-164, VEGF164, Vasculotropin

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About This Item

MDL-Nummer:
MFCD01636149
UNSPSC-Code:
12352202
NACRES:
NA.32

Produktbezeichnung

Vascular Endothelial Growth Factor 164 from rat, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Biologische Quelle

rat

Qualitätsniveau

200

Rekombinant

expressed in NSO cells

Assay

>95% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

1.08 ng/mL ED50

Mol-Gew.

dimer 50 kDa by SDS-PAGE
monomer 25 kDa by SDS-PAGE

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Verunreinigungen

endotoxin, tested

UniProt-Hinterlegungsnummer

P16612

Lagertemp.

−20°C

Angaben zum Gen

rat ... Vegfa(83785)

Anwendung

Vascular Endothelial Growth Factor 164 (VEGF 164) from rat was used for cardiomyocytes culture and Ca2+ transients′ measurement. It was used as a medium M-199 supplement utilized in in vitro incubation for examining the capability of CTS to limit the impact of biologically relevant molecules, in particular epidermal growth factor (EGF), basic fibroblast growth factor (FGF2), and vascular endothelial growth factor A (VEGFA) in rat epididymis segment 1 and 2.

Biochem./physiol. Wirkung

Mitogen for endothelial cells, enhances vascular permeability, activates, and chemoattracts monocytes and is a procoagulant.
Vascular Endothelial Growth Factor 164 also referred to as VEGF 164 or Vasculotropin is a growth factor that induces endothelial cell growth, vasculogenesis and angiogenesis. VEGF 164 can enhance collagen and fibronectin expression in mesangial cells which in turn stimulates TGF-β1-induced extracellular matrix. It also plays a pivotal role in progressive glomerular fibrosis.

Sonstige Hinweise

164 amino acid variant of rat VEGF.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% TFA containing 0.5 mg bovine serum albumin.

Hinweis zur Analyse

The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
SLCJ9173
SLCJ1716
071M1497V
110M1260
050M1589

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Die Dokumentenbibliothek aufrufen

Jose L Tomsig et al.
Biology of reproduction, 75(4), 598-604 (2006-07-21)
Previous evidence has shown that sperm maturation is the result of successive events that influence sperm cells as they move through different microenvironments from the caput to the cauda epididymis. The physiological basis for the creation and maintenance of specific
Mujun Sun et al.
Frontiers in molecular neuroscience, 15, 937350-937350 (2022-11-18)
Mild traumatic brain injury (mTBI) is a common and unmet clinical issue, with limited treatments available to improve recovery. The cerebrovascular system is vital to provide oxygen and nutrition to the brain, and a growing body of research indicates that
Wolfgang Rottbauer et al.
Genes & development, 19(13), 1624-1634 (2005-07-07)
The strength of the heart beat can accommodate in seconds to changes in blood pressure or flow. The mechanism for such homeostatic adaptation is unknown. We sought the cause of poor contractility in the heart of the embryonic zebrafish with
Lin Wang et al.
The Journal of biological chemistry, 279(32), 33213-33219 (2004-05-15)
Transforming growth factor-beta1 (TGF-beta1) is a potent inducer of extracellular matrix synthesis leading to progressive glomerular fibrosis. The intracellular signaling mechanisms involved in this process remain incompletely understood. The p38 mitogen-activated protein kinase (MAPK) is a major stress signal transducing
G Neufeld et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13(1), 9-22 (1999-01-05)
Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a single VEGF gene. These isoforms differ in their molecular mass and in biological
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Artikel

Vascular Endothelial Growth Factors (VEGF)

Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell migration, proliferation, tube formation, and survival. In the developing embryo VEGF-A mRNA is expressed by cells within tissues undergoing capillarization.

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