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V100

(±)-Vesamicol hydrochloride

Name: (±)-Vesamicol hydrochloride
Brand: SIGMA

>98%, solid

Synonym(e):

(±)-2-(4-Phenylpiperidino)cyclohexanol hydrochloride, AH-5183 hydrochloride

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About This Item

Empirische Formel (Hill-System):

C₁₇H₂₅NO · HCl

CAS-Nummer:

120447-62-3

Molekulargewicht:

295.85

MDL-Nummer:

MFCD00055231

UNSPSC-Code:

12352200

PubChem Substanz-ID:

24277880

Assay

>98%

Form

solid

Farbe

white

Löslichkeit

aqueous buffers below pH 8: 1 mM
DMSO: soluble
ethanol: soluble

SMILES String

Cl.OC1CCCCC1N2CCC(CC2)c3ccccc3

InChI

1S/C17H25NO.ClH/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14;/h1-3,6-7,15-17,19H,4-5,8-13H2;1H

InChIKey

XJNUHVMJVWOYCW-UHFFFAOYSA-N

Angaben zum Gen

human ... SLC18A3(6572)

Biochem./physiol. Wirkung

Potent inhibitor of vesicular acetylcholine storage.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Response of Pseudomonas putida to Complex, Aromatic-Rich Fractions from Biomass.

Mee-Rye Park et al.

ChemSusChem, 13(17), 4455-4467 (2020-03-12)

There is strong interest in the valorization of lignin to produce valuable products; however, its structural complexity has been a conversion bottleneck. Chemical pretreatment liberates lignin-derived soluble fractions that may be upgraded by bioconversion. Cholinium ionic liquid pretreatment of sorghum

The pharmacology of vesamicol: an inhibitor of the vesicular acetylcholine transporter.

C Prior et al.

General pharmacology, 23(6), 1017-1022 (1992-11-01)

1. Vesamicol (2-[4-phenylpiperidino] cyclohexanol) inhibits the transport of acetylcholine into synaptic vesicles in cholinergic nerve terminals. 2. Recent pharmacological studies of the effects of vesamicol on skeletal neuromuscular transmission have revealed a pattern of activity for the compound consistent with

Demonstration of a receptor in Torpedo synaptic vesicles for the acetylcholine storage blocker L-trans-2-(4-phenyl[3,4-3H]-piperidino) cyclohexanol.

B A Bahr et al.

Proceedings of the National Academy of Sciences of the United States of America, 83(7), 2267-2270 (1986-04-01)

Transport and storage of acetylcholine by purified Torpedo electric organ synaptic vesicles is blocked by the drug L-trans-2-(4-phenylpiperidino)cyclohexanol (AH-5183). This study sought evidence of a specific receptor for the drug. Highly tritiated L-trans-2-(4-phenyl [3,4-3H] piperidino)-cyclohexanol (L-[3H] AH5183) was synthesized. An

The vesicular acetylcholine transport system.

Marshall,L, et al.

Trends in Neurosciences, 10, 174-174 (1987)

Chemical genetics reveals a complex functional ground state of neural stem cells.

Phedias Diamandis et al.

Nature chemical biology, 3(5), 268-273 (2007-04-10)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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