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U4754

Sigma-Aldrich

Anti-Lectin, Ulex europaeus-I antibody produced in rabbit

whole antiserum, delipidized

Synonym(e):

Anti-Gorse or Furze Lectin, Anti-UEA-I

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About This Item

MDL-Nummer:
MFCD00162898
UNSPSC-Code:
12352203
NACRES:
NA.46

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

whole antiserum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

liquid

Enthält

15 mM sodium azide

Speziesreaktivität

Ulex europaeus

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:500 using human tissue

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Allgemeine Beschreibung

The antibody may be used for studies of the vascular structures. It reacts specifically with UEA-I bound to human endothelial cells of normal and neoplastic blood and lymphatic vessels. Its uniform reaction with vessels enables differentation between vessels and artificial slits in the tissue.

Immunogen

Ulex europaeus from gorse seeds..

Anwendung

Anti-Lectin, Ulex europaeus-I antibody produced in rabbit has been used in double immunostaining of muscle capillary sections.

Biochem./physiol. Wirkung

Lectin isolated from Ulex europaeus I is specific for α-L-fucose-containing glycocompounds. Due to this specificity it serves as a marker for vascular endothelial cells and tumors derived from them.

Zielbeschreibung

Lectins are highly specific carbohydrate binding proteins useful in carbohydrate and cell membrane studies, as well as cell agglutination and typing techniques.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Sigma-Aldrich

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H Holthöfer et al.
Laboratory investigation; a journal of technical methods and pathology, 47(1), 60-66 (1982-07-01)
Ulex europaeus I agglutinin, a lectin specific for some alpha-L-fucose-containing glycocompounds, was used in fluorescence microscopy to stain cryostat sections of human tissues. The endothelium of vessels of all sizes was stained ubiquitously in all tissues studied as judged by
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American journal of physiology. Gastrointestinal and liver physiology, 300(6), G1065-G1079 (2011-03-19)
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M Miettinen et al.
American journal of clinical pathology, 79(1), 32-36 (1983-01-01)
Some skin and soft tumors, which generally are assumed to be derived from endothelial cells or blood vessels, were characterized with fluorochrome-labeled Ulex europaeus I agglutinin (UEA I), recently shown to bind specifically to endothelial cells in various normal human
J M Sweeter et al.
Scientific reports, 11(1), 13037-13037 (2021-06-24)
Exacerbations of muco-obstructive airway diseases such as COPD and asthma are associated with epithelial changes termed mucous metaplasia (MM). Many molecular pathways triggering MM have been identified; however, the factors that regulate resolution are less well understood. We hypothesized that
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