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T8325

Sigma-Aldrich

TDZD-8

≥98% (HPLC), needles

Synonym(e):

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

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About This Item

Empirische Formel (Hill-System):
C10H10N2O2S
CAS-Nummer:
327036-89-5
Molekulargewicht:
222.26
MDL-Nummer:
MFCD04973552
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329826879
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

needles

Lagerbedingungen

protect from light

Farbe

white

mp (Schmelzpunkt)

63-64.4 °C

Löslichkeit

DMSO: >10 mg/mL

Lagertemp.

2-8°C

SMILES String

CN1SC(=O)N(Cc2ccccc2)C1=O

InChI

1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

InChIKey

JDSJDASOXWCHPN-UHFFFAOYSA-N

Anwendung

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Biochem./physiol. Wirkung

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

Leistungsmerkmale und Vorteile

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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