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T7515

Sigma-Aldrich

Sodium taurolithocholate

Synonym(e):

3α-Hydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Taurolithocholic acid sodium salt

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About This Item

Lineare Formel:
C26H44NO5SNa
CAS-Nummer:
6042-32-6
Molekulargewicht:
505.69
UNSPSC-Code:
12161900
PubChem Substanz-ID:
24900457
NACRES:
NA.25

Beschreibung

anionic

Qualitätsniveau

200

Assay

≥97.0% (TLC)

Mol-Gew.

505.69 g/mol

Anwendung(en)

detection

SMILES String

C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na]

InChI

1S/C26H45NO5S.Na.H/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3;;/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32);;/t17-,18-,19-,20+,21-,22+,23+,25+,26-;;/m1../s1

InChIKey

CMXYYIRKQPXCIE-RLHFEMFKSA-N

Allgemeine Beschreibung

Sodium taurolithocholate is a bile salt with detergent qualities that give it the ability to solubilize insoluble lipids.

Anwendung

Sodium taurolithocholate has been used in a study to assess factors controlling the gastrointestinal adsorption of petroleum hydrocarbon residues. It has also been used in a study to investigate the decrease in activity of Na+, K+-adenosinetriphosphatase (Na+, K+-ATPase) in rats where cholestasis had been induced.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Sohail Z Husain et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(12), G1423-G1433 (2012-04-21)
Biliary pancreatitis is the most common etiology for acute pancreatitis, yet its pathophysiological mechanism remains unclear. Ca(2+) signals generated within the pancreatic acinar cell initiate the early phase of pancreatitis, and bile acids can elicit anomalous acinar cell intracellular Ca(2+)
Xuejun Zhang et al.
The journal of physical chemistry. B, 115(49), 14445-14449 (2011-11-15)
Stimuli-responsive organic tubes are an attractive supramolecular assembly which has potential applications as a controlled release vehicle. We synthesize a smart organic tube by the coassembly of lithocholic acid (LCA) and taurolithocholic acid (TLCA) in aqueous solution. The coassembled LCA/TLCA
Kjell B Døving et al.
The Journal of experimental biology, 214(Pt 1), 80-87 (2010-12-15)
In the present study, we exposed the olfactory epithelia of crucian carp, Carassius carassius, and brown trout, Salmo trutta, to dextran coupled with Alexa dyes together with odorants. Dye uptake was severely reduced after pre-exposure to nocodazole, an inhibitor of
Hoi-Ying N Holman et al.
Environmental science & technology, 36(6), 1281-1286 (2002-04-12)
Petroleum hydrocarbon residues in weathered soils may pose risks to humans through the ingestion pathway. To understand the factors controlling their gastrointestinal (GI) absorption, a newly developed experimental extraction protocol was used to model the GI solubility of total petroleum
J Reichen et al.
Experientia, 35(9), 1186-1188 (1979-09-15)
Na +, K + -adenosinetriphosphatase (Na +, K + -ATPase) activity was decreased in liver plasma membranes from rats in which cholestasis had been induced by i.v. administration of sodium taurolithocholate (5 mumoles/100 g b. wt). Incubation of liver plasma
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Protokolle

Fast and Robust HPLC Separation of Bile Acids and Conjugates with Ascentis Express C18

This method is particularly useful in research into the role of individual bile acids as signaling molecules; suitable for clinical laboratories to investigate potential mechanisms linked to gut hormone profiles and glycemic control.

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