SRP8059

Jagged-2 (human): FC (human)

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

• Synonym(e): Alpha-ketoglutarate-dependent dioxygenase FTO, Protein jagged-2, hJ2
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Rekombinant: expressed in HEK 293 cells
• Assay: ≥90% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~150 kDa by SDS-PAGE
• Verunreinigungen: <0.1 EU/μgtested
• UniProt-Hinterlegungsnummer: Q9Y219
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... JAG2(3714)

Beschreibung

Allgemeine Beschreibung

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

Sequenz

Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.

Physikalische Form

Lyophilized. Contains PBS + 0.02 % CHAPS.

Rekonstituierung

Reconstitute with 100μl sterile water.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable