SRP4872
GDF9 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(e):
GDF9, Growth/differentiation factor 9
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)
About This Item
UNSPSC-Code:
12352202
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
human
Rekombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
Form
lyophilized
Mol-Gew.
~31.2 kDa
Verpackung
pkg of 20 μg
Verunreinigungen
endotoxin, tested
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
human ... GDF9(2661)
Allgemeine Beschreibung
GDF-9 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-3. Unlike most TGF-family members, GDF-9 and GDF-3 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. GDF-9 is expressed in oocytes and is required for normal ovarian folliculogenesis. Recombinant human GDF-9 is a 31.0 kDa non-disulfide-linked homodimer containing two 135 amino acid polypeptide chains with 6XHis on its N-terminus.
Anwendung
GDF9 has been as a supplement in the basal medium for the maturation of cumulus–oocyte complexes (COCs).
Biochem./physiol. Wirkung
Growth differentiation factor 9 (GDF9) is known to be localized in the cytoplasm. The gene encoding it is localized on human chromosome 5q31.1. It is known to be associated with granulosa cell proliferation and steroid production. Downregulation of the gene is observed in polycystic ovary syndrome.
Physikalische Form
Sterile filtered and lyophilized with no additives.
Rekonstituierung
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Reduced and delayed expression of GDF9 and BMP15 in ovarian tissues from women with polycystic ovary syndrome.
Wei LN
Journal of Assisted Reproduction and Genetics (2014)
Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure.
Laissue P
European Journal of Endocrinology (2006)
Impact of oocyte-secreted factors on its developmental competence in buffalo
Swati Gupta
Zygote (2017)
Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15.
Reader KL
Reproduction, Fertility, and Development (2016)
Jesús Cadenas et al.
Reproductive biology and endocrinology : RB&E, 20(1), 126-126 (2022-08-20)
The suggested effects of the oocyte secreted GDF9 and BMP15 growth factors on oocyte maturation are currently based on recombinant proteins, and little is known about native GDF9 and BMP15 in humans. Human immature cumulus-oocyte complexes (COCs) obtained in connection
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
Setzen Sie sich mit dem technischen Dienst in Verbindung.