SML3904

FerroLOXIN-1

≥96% (HPLC)

• Synonym(e): N-(3-Fluoro-4-(trifluoromethyl)benzyl)-1-(3-fluorophenyl)-4-phenyl-1H-imidazol-2-amine, N-[[3-Fluoro-4-(trifluoromethyl)phenyl]methyl]-1-(3-fluorophenyl)-4-phenyl-1H-imidazol-2-amine
• Empirische Formel (Hill-System): C₂₃H₁₆F₅N₃
• CAS-Nummer: 2773428-48-9
• Molekulargewicht: 429.39
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥96% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Versandbedingung: wet ice
• Lagertemp.: -10 to -25°C

Beschreibung

Biochem./physiol. Wirkung

15LOX/PEBP1 catalytic complex inhibitor that prevents cell death by ferroptosis, but not necroptosis, pyroptosis, or apoptosis.


FerroLOXIN-1 is a ferroptosis inhibitor that selectively targets the 15LOX/PEBP1 catalytic complex without affecting the biosynthesis of pro-/anti-inflammatory lipid mediators. FerroLOXIN-1 prevents 0.5 μM GPX4 inhibitor RSL3-induced ferroptosis in HBE cell cultures (IC50 = 84 nM post 20h RSL3 treatment) and rescues mice from total body irradiation (TBI)-induced death in vivo (Cpd administered via 25 mg/kg ip. 20h post 9.25Gy irradiation; survival on day 27 = 75% vs. 0% on day 19 of untreated control). FerroLOXIN-1 does not exert its efficacy via radical scavenging or iron-chelating activity, nor does it prevent cell death by necroptosis, pyroptosis, or apoptosis.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable