SML3825

MM0299

≥98% (HPLC)

• Synonym(e): 4,4a,5,5a,6,6a-Hexahydro-2-[4-[2-(4-methoxyphenyl)-2-oxoethoxy]phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione
• Empirische Formel (Hill-System): C₂₆H₂₃NO₅
• CAS-Nummer: 474255-10-2
• Molekulargewicht: 429.46
• MDL-Nummer: MFCD03145757
• UNSPSC-Code: 51111800
• UNSPSC-Code: 12352200
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: -10 to -25°C

Beschreibung

Biochem./physiol. Wirkung

MM0299 is a cell penetrant, selective and potent inhibitor of lanosterol synthase (LSS) that exhibits anti-glioblastoma activity. It potently inhibits Mut6 (Glioblastoma stem-like cells) cell growth by depleting cellular cholesterol. MM0299 stimulates 24(S),25-epoxycholesterol (EPC) synthesis in GBM tumors, which induces toxicity in glioma stem-like cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable