SML3420

KY-226

≥97% (HPLC)

• Synonym(e): 4-((Biphenyl-4-ylmethylthio)methyl)-N-(hexylsulfonyl)benzamide, 4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide, 4-[[([1,1′-Biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)benzamide
• Empirische Formel (Hill-System): C₂₇H₃₁NO₃S₂
• CAS-Nummer: 1621673-53-7
• Molekulargewicht: 481.67
• MDL-Nummer: MFCD32263946
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1
• InChI: 1S/C27H31NO3S2/c1-2-3-4-8-19-33(30,31)28-27(29)26-17-13-23(14-18-26)21-32-20-22-11-15-25(16-12-22)24-9-6-5-7-10-24/h5-7,9-18H,2-4,8,19-21H2,1H3,(H,28,29)
• InChIKey: MKXMABKUVSOEJF-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

KY-226 is an orally bioavailable, potent and selective allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) that does not function as a PPARg agonist. KY-226 exhibits anti-diabetic, anti-obesity effects by enhancement of insulin and leptin signaling in mice. It appears that KY-226 exerts neuroprotective effects through restoration of phosphorylation of Akt and FoxO1. Thus, it protects BBB integrity by restoration of tight junction (TJ) proteins in mice.

Orally bioavailable, potent and selective allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B)

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable