SML3340

Sgl1 inhibitor Hit 1

≥98% (HPLC)

• Synonym(e): 4-Hydroxy-1-[[2-(3-methoxyphenyl)-5-thiazolyl]methyl]-4-piperidinemethanol
• Empirische Formel (Hill-System): C₁₇H₂₂N₂O₃S
• CAS-Nummer: 1332191-15-7
• Molekulargewicht: 334.43
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: COC1=CC=CC(C2=NC=C(S2)CN3CCC(O)(CC3)CO)=C1
• InChIKey: FXCZNKJONOHACS-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1)

Sgl1 inhibitor Hit 1 is a cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1) that significantly increases in the intracellular concentration of ergosterol 3β-D-glucoside (erg-glc). Sgl1 inhibitor Hit 1 potently inhibits growth of wild-type C. neoformans. Also, it inhibits brain dissemination of C. neoformans in a mouse model of infection.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable