SML3312

SRI-41315

≥95% (HPLC)

• Synonym(e): 2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
• Empirische Formel (Hill-System): C₂₂H₁₉N₃O₂
• CAS-Nummer: 1613509-49-1
• Molekulargewicht: 357.41
• UNSPSC-Code: 51111800
• NACRES: NA.32

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Lagertemp.: -10 to -25°C
• SMILES String: O=C1N(C2=CC=CC=C2)C(C3CCC3)=NC4=C1C(C5=CC=CC=C5N4C)=O

Beschreibung

Biochem./physiol. Wirkung

SRI-41315 is a cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon and allows translation elongation to continue in the correct reading frame and generate a full-length protein. SRI-41315 induces the translational pause that occurs at premature termination codons by depleting eRF1 protein levels through a proteasome-mediated degradation pathway. SRI-41315 restores CFTR expression and function in in immortalized and primary human bronchial epithelial cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable