SML2675

CuET

≥97% (HPLC)

• Synonym(e): Copper bis(N,N-diethyldithiocarbamate), Cupric diethyldithiocarbamate, Merkupral, NSC 177697, bis(N,N-Diethyldithiocarbamato)copper(II)
• Empirische Formel (Hill-System): C₁₀H₂₀CuN₂S₄
• CAS-Nummer: 13681-87-3
• Molekulargewicht: 360.09
• MDL-Nummer: MFCD00070506
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥97% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: dark green to black
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CCN(CC)C(S[Cu]SC(N(CC)CC)=S)=S
• InChI: 1S/2C5H11NS2.Cu/c2*1-3-6(4-2)5(7)8;/h2*3-4H2,1-2H3,(H,7,8);/q;;+2/p-2
• InChIKey: OBBCYCYCTJQCCK-UHFFFAOYSA-L

Beschreibung

Biochem./physiol. Wirkung

CuET, a metabolite of disulfiram, is an inhibitor of p97 segregase adaptor NPL4 that exhibits potent anti-cancer effects. Apparently CuET binds NPL4 and induces its aggregation, which disables the vital p97–NPL4–UFD1 pathway and induces to cell death.

Inhibitor of NPL4

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable