SML2256

D3-βArr

≥98% (HPLC)

• Synonym(e): N-(1-Phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine, N-(1-Phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine
• Empirische Formel (Hill-System): C₂₀H₂₃N₅
• CAS-Nummer: 662164-09-2
• Molekulargewicht: 333.43
• MDL-Nummer: MFCD04077665
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CC(C1=CC=CC=C1)NC2=NC(N3CCNCC3)=NC4=CC=CC=C42
• InChI: 1S/C20H23N5/c1-15(16-7-3-2-4-8-16)22-19-17-9-5-6-10-18(17)23-20(24-19)25-13-11-21-12-14-25/h2-10,15,21H,11-14H2,1H3,(H,22,23,24)
• InChIKey: LOGWGZNWEWFTJV-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

D3-βArr is a positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling that initiates translocation of β-Arr 1 by direct TSHR activation, while showing no agonistic effect on cAMP production. D3-βarr is a positive allosteric modulator for TSH-enhanced osteoblast differentiation.

positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable