SML2244

AC1903

≥98% (HPLC)

• Synonym(e): N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
• Empirische Formel (Hill-System): C₁₉H₁₇N₃O
• CAS-Nummer: 831234-13-0
• Molekulargewicht: 303.36
• MDL-Nummer: MFCD06609959
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: C12=CC=CC=C1N=C(NCC3=CC=CO3)N2CC4=CC=CC=C4

Beschreibung

Anwendung

AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma.

Biochem./physiol. Wirkung

AC1903 is a specific inhibitor of TRPC5, the transient receptor potential canonical channel 5, a Ca²⁺ permeable nonselective cation channel highly expressed in brain and kidney. AC1903 did not inhibit TRPC4 or TRPC6 currents and showed no off-target effects in kinase profiling assays. It specifically blocked TRPC5 channel activity in glomeruli of proteinuric rats, suppressed severe proteinuria, showing a therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.

Chronic administration of AC1903 averts the loss of podocytes in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable