SML2064

LBQ657

≥97% (HPLC)

• Synonym(e): (2R,4S)-5-(Biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid, Desethyl sacubitril, Sacubitrilat
• Empirische Formel (Hill-System): C₂₂H₂₅NO₅
• CAS-Nummer: 149709-44-4
• Molekulargewicht: 383.44
• MDL-Nummer: MFCD00921225
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥97% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D -35 to -27°, c = 1 in methanol
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: OC(CCC(N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@H](C(O)=O)C)=O)=O
• InChI: 1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1
• InChIKey: DOBNVUFHFMVMDB-BEFAXECRSA-N

Beschreibung

Biochem./physiol. Wirkung

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H336,H372
• P-Sätze: P260 - P264 - P271 - P304 + P340 + P312 - P314 - P403 + P233
• Gefahreneinstufungen: STOT RE 1 - STOT SE 3
• Zielorgane: Bone,Kidney, Central nervous system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable